Released on November 22, 2019, the Kyrie 6 features a textile forefoot, leather rear, and a return of the midfoot strap that last appeared on the Kyrie 2. Zoom Air is present in the forefoot, and the familiar teeth design motif now appear on the inside heal area of the shoe.

While popular, the Kyrie 6 turned out to be a somewhat less common sight on the feet of NBA players than its predecessors, especially the Kyrie 4s and 5s.